Effects of Zhitangshu on The SOD Activity and MDA Level in Tissues of Diabetic Mice

Objective To Observe the effects of Zhitangshu (ZTS) on the superoxidatase (SOD) activivty and malondialdehyde (MDA) level in tissue of diabetic micec.Methods The diabetic model mice was prepared by alloxan (ip) and treated by drinking ZTS with defferent dose for a periode of 15 days,while the control group were treated with normal saline (diabetic model group),glibenclamide,phenformin and xiaoke pill,respectively.Then,the SOD activity and MDA level in tissues of heart,liver,pancreas and kidney of diabetic mice were mesaured.Statistic treatment was made with t-test.Results It was showed that the SOD activity in tissues of heart,liver,pancreas and kidncy were obviously increased and MDA decreased of ZTS group (ⅠⅡⅢ) in comparison with those of the diabetic model group (P0.05～0.001).The similar effects were also showed in glibenclamide,phenformin and xiaoke pill groups.There were no significant differences (P0.05) of the antilipid-peroxidative effect in heart,liver and kidney of diabetic mice.About the effect of enhancing pancreatic SOD activity,there was no significant difference between ZTS (≥10g/kg·d -1 ) and phenformin (13mg/kg·d -1 ),but the effect of ZTS was better than that of glibenclamide and xiaoke pill (P0.001).About the effect of reducing pancreatic MDA level,the ZTS (≥10g/kg·d -1 ) was the best among them.Conclusion ZTS has remarkable amtilipid-peroxidative effect in the tissue of diabetic mice.