Evaluation of multiple tumor marker protein biochip detective system in diagnosis of lung cancer

Objective To explore the clinical application value of multiple tumor marker protein biochip detective system in diagnosis of lung cancer. Methods Serum levels of twelve tumor markers such as CA19-9, NSE, CEA, CA242, CA125, CA153, AFP, ferritin, f-PSA, PSA, β-HCG and HGH in 276 healthy volunteers and 254 pathologically or cytological diagnosed lung cancer patients were measured and analysed with a C-12 multiple tumor marker protein biochip detective system respectively. Results The positive rate of the C-12 multiple tumor marker proteins in lung cancer group was significantly higher than that of healthy volunteers group (68.90% vs 17.03%, χ2 = 152.95, P 0.01), the sensitivity and specificity was 68.9% and 82.9% respectively. The positive rates of ferritin, CA125, CEA and CA19-9 were 41.04%, 35.86%, 33.47% and 13.15% respectively in lung cancer group. Conclusion C-12 multiple tumor marker protein biochip detective system has relatively high practical application value in the diagnosis of lung cancer.