The diagnostic value of multi-indicators detection of pleural effusion for differentiating malignant and benign pleural effusion

Objective To investigate the diagnostic value of carcinoembryonic antigen(CEA),C reactive protein(CRP),lactate dehydrogenase(LDH),adenosine deaminase(ADA) of pleural effusion for differentiating malignant and benign pleural effusion.Methods CEA,CRP,LDH,ADA in pleural effusion were detected in 90 patients with benign pleural effusion and 90 patients with malignant pleural effusion.ROC curve was used to evaluate the diagnostic sensitivity and negative predictive value of indicators above in differentiating benign and malignant pleural effusion.Results In benign pleural effusion,the level of CRP and ADA were higher than those in the patients with malignant pleural effusion,CEA,LDH were lower than those in the patirnts with malignant pleural effusion,the differences had significant difference(P 0.01).The positive rates of CRP and ADA in benign pleural effusion group were higher than those of malignant pleural effusion group,the positive rates of CEA and LDH were lower compared with malignant pleural effusion,the differences had significant difference(P 0.01).When the four indicators were combined detected,the sensitivity and negative predictive value improved significantly according to ROC curve.Conclusion The combined detection of CEA,CRP,LDH,ADA can greatly improve the diagnostic value of benign and malignant pleural effusion.