Effects of Finasteride Associated with Doxazosin on Rat Model of Benign Prostate Hypertrophy

Objective: To investigate effects of Finasteride associated with doxazosin on rat model of benign prostate hypertrophy.Method: 34 male Wistar rats were divided into sham operation group(n=6)and model group(n=28).After rat model was successful,The other 24 model rats were randomly divided into Finasteride associated with doxazosin group、Finasteride group、doxazosin group、negative control group.The four group rats were injected subcutaneously testosterone propionate 4mg/kg.d for four weeks;sham operation group was injected subcutaneously the same dose of olive oil for four weeks.All groups were killed at 4 weeks,removed the prostates,observed the structural changes of prostates by light microscopy,calculated the prostate index(PI).The expression of bax、fas、bcl-2 protein were analysed by means of immunohistochemical technique.Result: Compared with negative control group,PI、bcl-2 protein of Finasteride associated with doxazosin、Finasteride group were significantly decreased(P0.05),the expression of bax、fas protein significantly increased(P0.05).Conclusion: Finasteride associated with doxazosin can induce glandular atrophy of the rat model of BPH.Applications of Finasteride associated with doxazosin therapy could be candidated for the new treatment of BPH.