2008•Zhongguo shiyan fangjixue zazhiRequires access

Effect of Sanyangyixinkang Capsule on Acute Myocardial Ischemia in Dogs

Qīng Wáng

Abstract

Objective:To investigate the effect of Sanyangyixinkang Capsule on acute myocardial ischemia in dog.Methods:Acute myocardial infarction model in dog was established by ligating anterior descending coronary artery,using epicardial electrogram mapping to monitor the level of myocardial ischemia,using NBT histochemical stain to determine myocardial infarction size;using biochemical methods to determine AST,CPK,LDH;and using electron microscopy method to observe the morphologic changes of myocardial ischemia.Results:The drug can significantly reduce ∑-ST,N-ST,MIS,and serum AST and CPK levels.Conclusion:The drug has marked improvement and protection for acute myocardial ischemia in dog.

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Key concepts: Medicine, Myocardial infarction, Cardiology, Capsule, Ischemia, Internal medicine, Myocardial ischemia, Artery