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2003•Journal of Clinical Internal MedicineRequires access

Expressions of B7 on peripheral blood lymphocytes of patients with idiopathic thrombocytopenic purpura

Gao Qingpin

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Abstract

Objective To investigate the expressions of B7(B7-1?B7-2)on lymphocytes in peripheral mononuculear cells in patients with idiopathic thrombocytopenic purpura(ITP) .Methods The expressions of B7-1(CD 80 + )and B7-2(CD 86 + ) of peripheral lymphocytes were measured by flow cytometry in 30 ITP patients and 15 normal controls.Results The expression of CD 86 + on lymphocytes and the expression of CD 86 +(CD 19 +CD 86 +/CD 19 +) on B lymphocytes were higher in ITP patients than those in normal controls(P0.05),but the difference of the expressions of CD 80 + and CD 19 +CD 80 +/CD 19 + between ITP patients and normal controls were not significant,respectively(P0.05).Conclusion The change of CD 86 + expression is possibly related to pathophysiology in ITP.

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What this paper is about

Objective To investigate the expressions of B7(B7-1?B7-2)on lymphocytes in peripheral mononuculear cells in patients with idiopathic thrombocytopenic purpura(ITP) .Methods The expressions of B7-1(CD 80 + )and B7-2(CD 86 + ) of peripheral lymphocytes were measured by flow cytometry in 30 ITP patients and 15 normal controls.Results The expression of CD 86 + on lymphocytes and the expression of CD 86 +(CD 19 +CD 86 +/CD 19 +) on B lymphocytes were higher in ITP patients than those in normal controls(P0.05),but the difference of the expressions of CD 80 + and CD 19 +CD 80 +/CD 19 + between ITP patients and normal controls were not significant,respectively(P0.05).Conclusion The change of CD 86 + expression is possibly related to pathophysiology in ITP.

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Available abstract

Objective To investigate the expressions of B7(B7-1?B7-2)on lymphocytes in peripheral mononuculear cells in patients with idiopathic thrombocytopenic purpura(ITP) .Methods The expressions of B7-1(CD 80 + )and B7-2(CD 86 + ) of peripheral lymphocytes were measured by flow cytometry in 30 ITP patients and 15 normal controls.Results The expression of CD 86 + on lymphocytes and the expression of CD 86 +(CD 19 +CD 86 +/CD 19 +) on B lymphocytes were higher in ITP patients than those in normal controls(P0.05),but the difference of the expressions of CD 80 + and CD 19 +CD 80 +/CD 19 + between ITP patients and normal controls were not significant,respectively(P0.05).Conclusion The change of CD 86 + expression is possibly related to pathophysiology in ITP.

Key concepts: Medicine, Thrombocytopenic purpura, Peripheral blood, Peripheral, Flow cytometry, Pathophysiology, Immunology, Immune system

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