Analyisis of drug resistance of hospital-acquired yeast-like fungi

Objective To investigate the current drug resistance status of hospital-acquired yeast-like fungi to commonly used antifungal agents,and to provide reference for clinical therapy.Methods A total of 115 isolates of Candida spp were cultured according to the routine method and isolated with colourable Candida culture medium.The drug susceptibility was determined by broth microdilution method.Results Among the 115 strains of yeast-like fungi,the detection number(rate) of Candida albicans accounted for 49(42.6%),Candida glabrata 16(13.9%),Candida parapsilosis 16(13.9%),Candida tropitalis 12(10.4%),Candida krusei 11(9.6%),Candida guilliermondii 8(6.9%).The resistant rates of Candida spp to amphotericin B,5-flucytosine,nystatin,miconazole,itraconazole,fluconazole and ketoconazole were 3.5%,1.7%,13.0%,25.2%,23.5%,26.1% and 22.6% respectively.Conclusion Candida albicans is the most common pathogen of hospital-acquired yeast-like fungus infection,which is more resistant to fluconazole than the other antifungal agents.Detection of fungi should be paid emphasis upon,and therapeutic regimen should be adopted according to the drug resistance characteristics of isolated strains.