Distribution and drug resistance of 599 strains of Candida infection

Objective To understand the clinical Candida infection types,distribution and the susceptibility to common antifungal agents,to provide reliable basis for clinical diagnose and treatment.Methods The fungi was isolated and cultureed by using the conventional methods.From January 2010 to December 2011,in the Fifth Affiliated Hospital of Xinjiang Medical University,599 strains of Candida albicans were evaluated with CHRO Magar Candida chromogenic medium for identification,microbial susceptibility was used to analyze antifungal drug susceptibility.Results(1) In 599 strains of Candida from constituent ratio,the positive rate of Candida mainly in sputum,which accounted for(89.8),next was urine(4.5%),the positive rate of Candida in the blood was at the least(0.7%).The yeast-like fungal disease species appeared diversification.(2) In 599 strains of Candida,a maximum of 372 cases were detected Candida albicans infection(62.1%),followed by Candida tropicalis(10.2%),59 cases(9.8%) of Candida glabrata,21 cases(3.5%) of Candida krusei Candida parapsilosis,16 cases(2.7%),the other Candida species in 70 cases(11.7%).(3) The results of drug sensitive test indicated that Candida was sensitive to 5-flucytosine,voltconazole,and had varying degrees of resistance on fluconazole and itraconazole.Conclusion Candida infections in hospitals is on the rise.Susceptibility monitoring is necessary,the clinician should use antifungal drugs,based on the results of drug sensitive test,in order to prevent fungal infection and drug resistance effectively.