Curative Effect of Self-made Jiedu Liangxue Huayu Decoction on Treating Henoch Sehonlen Purpura Nephritis (HSPN) and its Coagulation Function of Children

Objective:To explore clinical effect and its influence on coagulation of self-made Jiedu Liangxue Huayu Decoction for Henoch Sehonlen Purpura Nephritis(HSPN)in children.Methods:82 cases of HSPN children were randomly divided into two groups.Control group(n=41)was given hormone and tripterygium glycosides,and observation group(n=41)was given self-made Jiedu Liangxue Huayu Decoction additionally.The clinical effect,renal function and coagulation were observed.Results:The clinical effect in observation group was 90.2%,were significantly higher than that in control group 73.2%(P0.05).The urinary red blood cells,urinary protein and β-microglobulin in both groups was reduced after treatment,while these indicators in observation group were reduced more remarkably than those in control group(P0.05).The coagulation in both groups was improved after treatment,while the level of APTT,PT,FIB and DD in observation group were significantly different with those in control group(P0.05).Conclusion:It is effective and safe of self-made Jiedu Liangxue Huayu Decoction in treating HSPN in children,it can contribute to regulate immune function,improve renal function and coagulation function.