Experimental study of the protective effect of Rhubarb on the intestinal barrier of rats with severe acute pancreatitis

Objective To observe the effect of Rhubarb on the intestinal barrier of rats with severe acute pancreatitis (SAP).Methods SAP model of rats was induced by injecting adversely the 3.5% sodium taurocholate into the biliopancreatic duct, and saline was used in the rats of sham operation group instead of sodium taurocholate, and catheters were placed into the jejunum via gastrostomy for all rats. The 24 rats with SAP were randomly divided into two groups, group A(n=12) used Rhubarb decoction and group B used saline instead, and there were 8 rats in sham operation group. Rhubarb decoction was used after 48 hours of model making. The indexes observed were intestinal transmit index, bacterial translocation rate, serum amylase, histological score of the pancreas and the level of D lactate. Results Group A had a significantly higher intestinal transmit index, with a lower translocation organ bacterial rate and plasma D lactate, compared with that of group B (P0.05). There was no difference in serum amylase and histological scores between the two groups (P0.05).Conclusion The jejunal administration of rhubarb decoction can help to the restoration of intestinal function and the protection of intestinal barrier, but which can't improve the state of SAP.