Analysis of distribution and antibiotic resistance of pathogenic bacteria in PICU of Guangzhou Children's Hospital.

Objective To investigate the distribution and antibiotic resistance of pathogenic bacteria in PICU and to provide evidence for use of antibiotics rationally.Method All the pathogenic bacteria isolated from pediatric intensive care unit of our hospital from Nov.2003 to Oct.2005 were retrospectively analyzed.Results Gram negative bacteria was the most prevalent strains and accounted for 72.2% in 295 strains isolated.Gram positive bacteria and fungi accounted for 19.7% and 8.1% respectively.Pseudomonas aeruginosa and Acinetobacter were the main strains of Gram negative bacteria and coagulase-negative staphylococcus was the main strains of Gram positive bacteria.The antibiotic resistance of Enterobacteriaceae to ampicillin,ampicillin/sulbactam,piperacillin and cephalosporin were higher,but to imipenem,cefoperazone/sulbactam and amikacin were lower.Acinetobacter was resistant to most of monitored antibiotics,except for imipenem,cefoperazone/sulbactam.Pseudomonas aeruginosa was resistant to Cefotaxime but susceptible to the others.Staphylococcus was highly resistant to penicillin and erythromycin but susceptible to vancomycin,teicoplanin and amikacin.Conclusions Pseudomonas aeruginosa was the most prevalent strains isolated in PICU.It was important for clinic using antibiotics rationally according to drug sensitivity test.