Expressions of MMP-2 and PTEN in colorectal carcinoma

Objective To explore the expressions of tumor-related genes (MMP-2 and PTEN) in colorectal carcinoma tissues and their clinic pathological significances. Methods The expressions of MMP-2 and PTEN in 40 patients with colorectal carcinoma were investigated by RT-PCR. Results ①There existed significant differences of the expressions of MMP-2 and PTEN between normal control and Dukes A,B (P0.01); as well as the expressions of MMP-2 and PTEN between Dukes C,D and Dukes A,B(P0.05); ②There existed significant differences of the expression rates of MMP-2 and PTEN between the high or middle differentiation grade of the carcinoma and the low differentiation grade (P0.05);③There existed significant differences of the expression rates of MMP-2 and PTEN between the patients with lymph metastasis and those without lymph metastasis (P0.05). Conclusion The expressions of MMP-2 and PTEN have close relationship with the pathology of colorectal carcinoma and their own biology behaviors. Both MMP-2 and PTEN play important roles in distincting hyperplasia of colorectal carcinoma.