2006•Zhongliu fangzhi yanjiuRequires access
Expression of PTEN in Colorectal Carcinoma
Meng Dong-yue
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Abstract
Objective To investigate the expression of PTEN in colorectal carcinoma and its relationship to invasion and metastasis. Methods SP immunohistochemical technique was used to assess the expression of PTEN, E-cad and MMP-2 in 67 cases of colorectal carcinoma. Five cases of normal colorectal tissues were served as control. Results The PTEN positive reaction was seen in cytoplasm. Compared with normal colorectal tissues, the expression of PTEN in the colorectal carcinoma was lower in both positive rate and intensity. The expression of PTEN was decreased as decrease in the degree of differentiation, and lower in lymph node metastasis group than that of in none lymph node metastasis group. Its expression in the cancer tissues was negatively correlated with the depth of invasion. PTEN expression in colorectal carcinoma was positively correlated with E-cad and negatively correlated with MMP-2. The cases of low PTEN and E-cad expression and high MMP-2 expression in lymph node metastasis group were more than that of in none lymph node metastasis group. Conclusions The low expression of PTEN and E-cad and high expression of MMP-2 may have correlative effects on the invasion and metastasis of colorectal carcinoma. The expression of PTEN, E-cad and MMP-2 may be useful biomarkers in the evaluation of the invasion and metastasis of colorectal carcinoma and may provide some evidence for the treatment of colorectal carcinomas.[JP]