Influence of Xingnaojing injection(醒脑静注射液) on cytokines and lung infection in patients with severe craniocerebral injury

Objective: To observe the influence of Xingnaojing injection(醒脑静注射液) on serum(cytokine) levels and lung infection in patients with severe craniocerebral injury.Methods: Eightyseven cases with craniocerebral injury(Glascow coma scale(8) were randomly divided into two groups: treatment group and control group.In the treatment group(n=43),Xingnaojing injection was added on the basis of(conventional) treatment after injury or operation,and in the control group(n=44) only conventional treatment was used.Results: After treatment,in the treatment group,the revival rate within 1 week,the decreasing level of tumor necrosis factor(TNF),interleukin2(IL2) and IL6 were superior to those of the control group,(compared with those before treatment in the treatment group and those after treatment in the(control) group(all P0.01)).The incidence of lung infection in the treatment group was lower than that in the(control) group(65.12% to 31.82%,P0.01).The difference of the mortality in the two groups was not(significant)(11.63% to 15.91%,P0.05).Conclusion: Xingnaojing injection in treatment for(severe)(craniocerebral) injuries not only can improve the revival rate within 1 week,but also can decrease the level of cytokine and the incidence of lung infection.