Clinical study on hyperthyroidism in pregnancy

Objective To study the changes of thyroid function of hyperthyroidism in pregnancies,and the effects on gestation and the fetus with propylthiouracil(PTU).Methods Clinical data of 42 cases of hyperthyroidism in pregnancies were analyzed retrospectively.Results There were overt clinical symptoms of hyperthyroidism in 29cases of 42 cases.The clinical symptoms of hyperthyroidism in 20 cases were controlled after treatment,and newborns were healthy(only one case with temporary neonatal hypothyroidism).There were 9 cases did not controlled(1 case with spontaneous abortion,4 cases with artificial abortions,3 cases with low-weight newborns,1 case giving up treatment for hypertension syndrome of pregnancy and thyrotoxic crisis).Conclusion Hyperthyroidism can be induced,recurred or worsened during different gestation period.It can result in serious outcome in hyperthyroidism of pregnancy,and bad effects on the fetus and the neonate,and it can be obviously improved the progonosis with PTU treatment.