The influence and curative effect of mouse nerve growth factor on high-sensitivity C-reactive protein(hs-CRP) and neuron-specific enolase(NSE) in blood serum of acute cerebral infarction patients

Objective To discuss the influence and curative effect of mouse nerve growth factor on high-sensitivity C- reactive protein(hs-CRP) and neuron-specific enolase(NSE) in blood serum of acute cerebral infarction patients. Methods 72 cases of acute cerebral infarction patients were divided into observation group and control group. All patients were given symptomatic and supportive treatment routinely like,intracranial pressure control, blood pressure and blood sugar control, platelet aggregation, brain cells protection, prevention and treatment of complications,and etc. The patients in observation group were given mouse nerve growth factor(18 μg) by intramuscular injection one time daily for 2 weeks. Results After 2 weeks' medical treatment,the serum hs-CRP and NSE levels of patients in two groups obviously were declined than before(P0.05 or P0.01),and the declining rate of observation group was much higher than that in control group(P0.05). Meanwhile,NHSS scores of patients in two groups were declined obviously than before(P0.05 or P0.01),while the FMA scores were rose obviously than before(P0.05 or P0.01),and declin- ing/rising rate of observation group was much higher than that the control group(P0.05). 3 cases(8.33%) and 6 cases(16.67%) cases of untoward effect appeared in control group and observation group with light DAR during the medical treatment. After comparing the untoward effect occurrence rates during the medical treatment, on obvious statistical differences appear(χ2=0.51,P0.05). Conclusion Mouse nerve growth factor has good clinical curative effect on acute cerebral infarction with security,and can obviously improve the function of nerve and body movement of patients,whose mechanism of action has close effect on reducing the serum hs-CRP and NSE levels.