The relationship between leptin and insulin in the hyperglycemic rats induced by high-fat feeding

The high fat(HF) diet elicite insulin resistance and diabetes mellitus in rats We studied the relationship between blood leptin and insulin during productive diabetes Rats were divided into two groups: control chow diet fed and high fat fed rats, and compared the levels of blood glucose, leptin and insulin levels at beginning and after 30 and 60 days respectively, at last applied euglycemic hyperinsulinemic clamps to each rats, weighed the fat HFF rats got significant insulin resistance, fat, leptin and insulin levels in them were markedly higher than those in control group About 50 percent HFF rats suffered from hyperglycemic(FBG8 3mmol/L), and the final weight was not different between diabetes and control rats The positive correlation among leptin and weight, insulin, blood glucose in all subjects The results indicate that (1)High fat diet can induce insulin resistance and diabetes;(2)the positive correlation between fat and diabetes; (3)leptin resistance might take part in insulin resistance and diabetes; (4)leptin can regulate weight and its level increases with aging