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2007•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Toxicity Study on DingLiJian Capsule

YU Guo-qiang

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Abstract

BACKGROUND AIM:DingLiJian capsule is a constituent of herbal medicine composed of ant powder compounded preparation.It was necessary to make toxicological assessment of DingLiJian capsule.MATERIALS AND METHODS:The acute toxicity in mice and rat,micronuclei test of bone marrow cell in mice,sperm shape abnormality test in mice and Ames test were used.RESULTS:The maximum tolerated dose(MTD)of rats and mice was more than 20.0 g/kg,so the DingLiJian capsule belonged to non-toxic substance;the results of micronucleus test of bone marrow cell,sperm shape abnormallty test in mice and Ames test were negative.CONCLUSION:The DingLiJian capsule has no acute toxicity and abnormality.

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What this paper is about

BACKGROUND AIM:DingLiJian capsule is a constituent of herbal medicine composed of ant powder compounded preparation.It was necessary to make toxicological assessment of DingLiJian capsule.MATERIALS AND METHODS:The acute toxicity in mice and rat,micronuclei test of bone marrow cell in mice,sperm shape abnormality test in mice and Ames test were used.RESULTS:The maximum tolerated dose(MTD)of rats and mice was more than 20.0 g/kg,so the DingLiJian capsule belonged to non-toxic substance;the results of micronucleus test of bone marrow cell,sperm shape abnormallty test in mice and Ames test were negative.CONCLUSION:The DingLiJian capsule has no acute toxicity and abnormality.

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Available abstract

BACKGROUND AIM:DingLiJian capsule is a constituent of herbal medicine composed of ant powder compounded preparation.It was necessary to make toxicological assessment of DingLiJian capsule.MATERIALS AND METHODS:The acute toxicity in mice and rat,micronuclei test of bone marrow cell in mice,sperm shape abnormality test in mice and Ames test were used.RESULTS:The maximum tolerated dose(MTD)of rats and mice was more than 20.0 g/kg,so the DingLiJian capsule belonged to non-toxic substance;the results of micronucleus test of bone marrow cell,sperm shape abnormallty test in mice and Ames test were negative.CONCLUSION:The DingLiJian capsule has no acute toxicity and abnormality.

Key concepts: Micronucleus test, Capsule, Ames test, Toxicity, Bone marrow, Acute toxicity, Sperm, Medicine

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