Effects of Triptorelin for Iidiopathic Central Precocious Puberty in Girls

OBJECTIVE:To evaluate the efficacy of the GnRHa triporelin for girls with idiopathic central precocious puberty(ICPP).METHODS:Totally 68 girls confirmed as having ICPP were treated with triporelin for 1-2 years,with the volume of uterus and ovary,LH(luteinizing hormone)peak,follicle stimulating hormone(FSH)peak,serum level of E2,body mass index(BMI),bone age,bone age/age(BA/CA),predicted adult height(PAH),height standard deviation score for bone age(HtSDSBA),dynamic change in growth velocity(GV)the drug side effects followed. Meanwhile,another 52 cases of untreated ICPP children were assigned to control group and followed up for 1 to 2 years with regard to the changes in the volume of uterus and ovary,LH peak,FSH peak,BMI and BA. The indexes were compared between the two groups. RESULTS:After treated with triporelin,the volume of breast,uterus and ovary dwindled significantly;the peak levels of serum LH and FSH and serum E2level were also significantly reduced,with delayed maturation of BA,decrease in BA/CA ratio,improvement in HtSDSBA and the predicted adult height(PHA),and the differences were statistically significant(P0.05);however,in the control group,the volume of breast,uterus and ovaries increased in varying degrees,the BA progressed and the BA/CA ratio increased. CONCLUSIONS:Treatment with triporelin can effectively suppress the hypothalamic-pituitary-gonadal and sex characteristic development,delay the BA maturation and finally improve the adult height in girls with ICPP.