Final adult height and side effects of gonadotropin releasing hormone analogue treatment in 23 girls with idiopathic central precocious puberty

Objective To evaluate the effect of gonadotropin releasing hormone analogue (GnRHa) treatment on the actual final adult height (FH) in girls with idiopathic central precocious puberty (ICPP) and to observe the side effects.Methods Twenty-three girls with ICPP were followed for 45.0 ± 14.2 months after the discontinuation of GnRHa treatment.The FH,the time of menarche,menstrual cycle regulatory,and body mass index (BMI) were observed.The accuracy of predicted adult height (PAH) by three methods were compared.Results The 23 girls with ICPP were treated by GnRHa for (24.3 ± 13.1) months.The mean FH was (160.3 ± 4.2) cm,significantly higher than PAH before treatment (-0.01 ± 1.53 SD vs-1.58 ± 2.02 SD,P 0.01).The menarche occurred (11.5 ± 5.5) months after the discontinuation of the treatment.All girls have a regular menstrual cycle.The BMI was 20.81 ± 2.08 when the girls achieved FAH.The PAH by G-P and TW3 methods were not significantly different from FH,but both of them were significantly higher than PAH by growth curves when the treatment was discontined.Conclusions GnRHa treatment was effectively improved the FH in girls with ICPP and was no adverse effects.