2008•Zhongguo xin yao zazhiRequires access

Spectrophotometric determination of azithromycin in dispersible tablets based on charge transfer reaction

Xuemin Zhou

Abstract

Objective:To establish a method for rapid determination of azithromycin in dispersible tablets.Methods:Using visible spectrophotometry based on the charge transfer reaction,the content of azithromycin was determined with azithromycin as donor and alizarin red as acceptor in alcohol-water solution.Results:The apparent molar absorptivity of complex was 1.23×104 L·mol-1·cm-1 at 536 nm.Beer law was obeyed in the range of 10～60 mg·L-1 for azithromycin.The average recovery was 100.7%.Conclusion:The proposed method is stable,accurate,sensitive and rapid.It has been applied for the determination of azithromycin.

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Key concepts: Azithromycin, Molar absorptivity, Spectrophotometry, Chemistry, Chromatography, ALIZARIN RED, Analytical Chemistry (journal), Optics