Clinical investigation of the relation of BNP and the prognosis in acute myocardial infarction

Objective To investigate the relationship between BNP levels and the short-term prognosis in AMI. Methods A total number of 96 acute myocardial infarction patients were included. They were divided into two groups based on whether accepted PCI was done or not. The rapid plasma BNP levels were measured before treatment and the seventh day after AMI respectively. ECG, blood routine test, CK-MB, TnI and UCG were done. All patients were followed up for 30 days from the day of admission. Results In both groups the BNP levels increased immediately after admission, but there was no significant difference between the two groups. On the seventh day, the BNP levels in PCI group were dramatically decreased (P0.05). On the contrary, in the group without PCI the BNP level of anterior AMI increased (P 0.05). The BNP level on the seventh day was negatively correlated with the LVEF (r=0.549, P=0.001), but had positive correlation with the LVEDD (r=0.431; P=0.041). The BNP levels of the first day and seventh day were markedly correlated with the occurrence of heart failure (P1=0.003; P7=0.005) and total cardiovascular events (P1=0.001; P7=0.006). Conclusions The plasma BNP level was a predictor of occurrence of cardiovascular events in AMI patients. The BNP level can be a way to evaluate the treatment efficiency of different treatment approaches in acute myocardial infarction patients.