The effect of application tramadol combined with low-dose naloxone on patients postoperative controlled intravenous analgesia

Objective To observe the analgesia and adverse effects of postoperative controlled intravenous analgesia (PCIA) with tramadol combined with low-dose naloxone.Methods Ninety patients undergoing laparoscopic hysterectomy were randomly divided into 3 groups with 30 cases each. Group N1: tramadol 1 000 mg combined with naloxone 0.4 mg. Group N2: tramadol 1 000 mg combined with naloxone 1.5 mg, group T: tramadol 1 000 mg.The numeric rating scale (NRS) was used in patients analgesia.Consumption of fentangl NRS of different time and consumption of tramadol were recorded.Results Patients in group N2 got higher NRS scores at rest compared with other groups at 2 and 8 hours postoperatively(P0.05). While coughing, patients in group N1 chose lower NRS than group T and N2 at 2 h postoperativly(P0.05) and NRS of group T were lower than group N2. Patients in group N1 chose lowest NRS compared with other groups (P0.05). Patients in group N1 consumed less tramadol in 24 h than in other groups (P0.05). The incidence of nausea and vomiting in group N1 was lower than in other groups (P0.05).Conclusion Tramadol combined with low-dose naloxone with PCIA can enhance analgesic effect with less drug consumption and less adverse effects.