Study on the Acute Toxicity Test of Ivermectin Injection in Mice

In order to observe the actue toxicity of long-action Ivermectin injection,modifited Korbor's method was used to study acute toxicity in mice.Mice were injected with different concentrations of long-action ivermectin in a 1∶0.7 intergroup doses,and observed for 7 days.The results showed that the LD50 of long-action ivermectin injection was 257.04 mg/kg,and 95% confidence limit was 192.84-342.61 mg/kg.The results confirmed that long-ation ivermectin injection belongs to hypotoxicity and it is safe to inject subcutaneously.