Monitoring of antimicrobial resistance of Streptococcus pneumoniae

OBJECTIVE To understand the distribution of clinical isolates of Streptococcus pneumoniae,analyze the characteristics of specimen sources,monitor the drug resistance,and compare with the surveillance data both in China and abroad so as to provide guidance for effective control of infections.METHODS From Jan 1,2011to Mar31,2013,totally 348clinical isolates of S.pneumoniae were collected,then the MIC values to penicillin and ceftriaxone were determined with the use of E-test method,the drug susceptibility testing was performed for other antibiotics by using K-B method,and the statistical analysis was performed with the use of WHONET5.6software.RESULTS Of the 348strains of S.pneumoniae,196(56.3%)strains were isolated from the wards of pediatrics department,and 341(98.0%)strains were isolated from respiratory tract specimens.The isolation rate of penicillin-non-susceptible S.pneumoniae was 3.5%,and the isolation rate of penicillin-resistant S.pneumoniae was0.6%.The drug susceptibility rates of the S.pneumoniae to penicillin,ceftriaxone,and fluoroquinolone varied from 81.3%to 98.9%,and the drug susceptibility rates of the S.pneumoniae to erythromycin and clindamycin were the lowest(less than 4.0%).CONCLUSIONThe S.pneumoniae strains are highly resistant to erythromycin and clindamycin and remain highly susceptible to penicillin,ceftriaxone,and fluoroquinolone.It is suggested that the blood culture specimens should be submitted in early stage of the S.pneumoniaeinfection to increase the isolation rate of the pathogens and that great attention should be paid to the bacterial drug resistance so as to reasonably use antibiotics based on the result of drug susceptibility testing.