Association study of genetic polymorphisms of alpha-adducin and angiotensinogen with essential hypertension in Shanxi population

Objective This case-control study was designed to investigate the association between angiotensinogen gene polymorphisms and alpha-adducin polymorphisms and essential hypertension(EH).Methods A case-control study was conducted using performed mutagenically separated polymerase chain reactions(MS-PCR) techniques to explore the AGT gene M235T polymorphisms and the ADD1 gene Gly460Trp polymorphisms in 299 EH and 218 normotensives(NT) of Shanxi Province.Results The genotypes distribution of TT in EH cases was significantly higher than in NH cases(P0.001),but not the alletic frequency of T(0.426 vs.0.378,P=0.121).No significant difference were seen in the genotype distribution and the alletic frequency of ADD1 gene between EH and NH cases(P=0.306,P=0.072).The genotype distribution of TT+TT was significantly higher to get EH.(MT+GG:OR=0.410,P=0.041;MT+GT:OR=0.364,P=0.020;MT+TT:OR=0.262,P=0.002).Those who exposed to TT genotype of AGT gene was the easiest to get EH.(MM:OR=0.502,P=0.019;MT:OR=0.306,P0.001).Conclusions The AGT M235T polymorphism might be associated with EH in Shanxi population.TT genotype might be associated with the increased risk of EH.AGT M235T polymorphism might have a gene-gene synergetic effect with Gly460Trp polymorphism.