Relationship between angiotensinogen gene M235T polymorphism and essential hypertension in Chongqing

Objective To investigate the association between M235T allele polymorphism in exon 2 of angiotensinogen (AGT) gene and essential hypertension(EH). Method Polymerase chain reaction combined with restrict enzyme digestion was used to detect the target gene polymorphism in 80 normotensive controls and 92 hypertensive patients. Result The frequencies of T allele and TT genotype were significantly higher in hypertensive patients than in normotensive controls( 79.3% vs 66.9%;64.1% vs 50%,respectively ). The odds ratio exposed to TT genotype was 3.835 comparing with MM genotype (P0.05). It was suggested that TT genotype be the susceptible genotype to EH in Chongqing. The odds ratio exposed to T allele was 1.903 comparing with M allele (P0.01). That means that the risk of EH has increased with the T allele frequency increasing.Conclusion AGT M235T gene polymorphism is closely associated with essential hypertension in Chongqing. TT genotype may be susceptible genotype to EH in Chongqing.