Meta-analysis on correlation of CD14-159C/T polymorphism to coronary disease

Objective To study the correlation between the CD14 gene promoter polymorphism-159C/T and coronary heart disease(CHD) by means of Meta-analysis. Methods All case-controll studies were searched,which were about correlation of CD14-159C/T polymorphism to coronary disease published before March 1st,2012 in the PubMed,Web of science,CNKI,Wanfang and CBM datebases.Search words to find appropriate studies were coronary heart disease,coronary artery disease,coronary disease,CD14 and genetic polymorphism.Publication bias was tested by funnel plot and the combined odd ratios(OR)then were calculated.Three polymorphous models of CC vs CT+TT、TT vs CC+CC and T vs C based on risk gene exposure group and non risk gene exposure group were supposed and used to calculate OR.The software Review Manager(version 5.0) was used for Meta-analysis. Results Seven appropriate studies were adopted.Integrated 2 005 cases and 1 433 controls from studies adopted were analyzed.The results showed OR of polymorphous models of CC vs CT+TT,TT vs CC+CT and allele T vs the allele C were respectively 0.64(P0.05)and 1.33(P0.01)and 1.31(P0.05).After rejected two studies about different race,corresponding OR above three polymorphous models were 0.39(P0.01),1.76(P0.01)and 1.68(P0.01)respectively. Conclusions It is indicated that the-159C/T polymorphism in CD14 gene promoter is significantly associated with increased risk of coronary disease,the allele T may be a genetic risk factor for coronary disease.