Association between CD14 rs2569190 C>T polymorphism and ischemic stroke susceptibility: a meta-analysis based on 5,277 subjects

Introduction: Previous epidemiological studies have suggested that CD14 rs2569190 C>T polymorphism plays an important role in ischemic stroke (IS) risk, but the results were inconsistent. Therefore, we conducted a meta-analysis to determine the association between CD14 rs2569190 C>T polymorphism and IS susceptibility. Methods: Online databases were searched from inception up to July 1, 2018, for studies concerning CD14 rs2569190 C>T polymorphism and its association with IS susceptibility. ORs and corresponding 95% CIs were calculated in the genetic models of each polymorphism locus with Stata Version 14.0. Furthermore, heterogeneity, meta-regression, accumulative analyses, sensitivity analyses, and publication bias were examined. Results: Overall, 10 observed studies involving 5,277 subjects were included in this meta-analysis on CD14 rs2569190 C>T polymorphism. Generally, no significant associations were found between CD14 rs2569190 C>T polymorphism and IS risk (allele contrast of T vs C: OR =1.03, 95% CI =0.96–1.12, P =0.41, I 2 =27.8%; co-dominant models of CT vs CC: OR =1.01, 95% CI =0.81–1.25, P =0.95, I 2 =51.9%; co-dominant models of TT vs CC: OR =1.04, 95% CI =0.89–1.22, P =0.62, I 2 =25.1%; dominant model of CT + TT vs CC: OR =1.02, 95% CI =0.84–1.25, P =0.82, I 2 =51.4%; recessive model of TT vs CC + CT: OR =1.07, 95% CI =0.95–1.22, P =0.28, I 2 =0%), similar to the results in the subgroup analysis. Conclusion: The current evidence indicated that CD14 rs2569190 C>T polymorphism was not a critical risk factor for IS development. Keywords: CD14, ischemic stroke, polymorphism