GW24-e2207 Association between--1562 C>T polymorphism in the promoter region of matrix metalloproteinase-9 (MMP-9) and coronary artery disease: A meta-analysis

Objectives To determine the association between-1562 C>T polymorphism in the promoter region of matrix metalloproteinase-9 (MMP-9) and coronary artery disease (CAD) risk. Methods This meta-analysis was on the basis of 26 studies including 12,776 cases and 6,371 controls. The was assessed by the Q-statistic test and the I2-statistic test. Sensitivity analysis was conducted by sequentially omitting any single study and recalculating the ORs and 95% CIs. Funnel plots and Egger’s test were performed to test the potential publication bias. All the data were analysed by using STATA version 12.0. Results We found that-1562 C>T polymorphism did not contribute to susceptibility to CAD in the overall results (ORCC vs. TT= 0.99, 95% CI = 0.94-1.04, P heterogeneity= 1.000; ORCC + CT vs. TT = 0.99, 95% CI = 0.95-1.04, P heterogeneity= 1.000; ORCC vs. CT + TT= 0.96, 95% CI = 0.92-1.01, P heterogeneity= 0.992; ORallele C vs. allele T= 0.98, 95% CI = 0.95-1.01, P heterogeneity= 1.000; ORCT vs. TT= 0.98, 95% CI = 0.89-1.07, P heterogeneity = 1.000). But the stratified analysis by ethnicity and source of control indicated-1562 C>T polymorphism may be a risk factor for the CAD risk in Asians and hospital populations. Conclusions Our meta-analysis supported the fact that-1562 C>T polymorphism was not associated with the susceptibility to CAD. Further larger studies are required to confirm our findings.