Effects of fluoxetine on neural stem cells in hippocampus of chronic mild stress induced depression model rats

Objective To observe the effects of fluoxetine on neural stem cells in the hippocampus of chronic mild stress induced depression model rats.Methods Twenty-four rats were divided into control group,model group and fluoxetine group,eight rats in each group.Depression model rats were induced by chronic mild stress,and behavior change was measured by open-field method.The expression of Nestin was detected by immunohistochemistry to evaluate the proliferation of hippocampcal neural stem cells.Results In model group,the behavior and hippocampal Nestin expression were decreased than those in control group;but in fluoxetine group,the behavior and Nestin expression were increased compared with those in model group,the differences were significant(P0.05).Conclusion Fluoxetine can reverse the behavioral change of the depression model rats,it may be related with mechanism of promoting the hippocampal nervous stem cells proliferation.