Therapeutic Effect of Breviscapine Combined with Enalapril on Early Diabetic Nephropathy

Objective To investigate the therapeutic effects of breviscapine combined with angiotensin converting enzyme inhibitor(enalapril) on early diabetic nephropathy.Methods A total of 59 patients with early diabetic nephropathy diagnosed between October 2006 and December 2009 were randomly divided into treatment group(n=30) and control group(n=29).The patients in treatment group were treated by breviscapine combined with enalapril,while the patients were treated with only enalapril in the control group.All of the patients were treated for three weeks.Urinaryalbuminexcretion(UAE),whole blood viscosity,plasma viscosity,triglycercide,blood urea nitrogen and serum creatinine in the two groups were detected before and after the treatment.Results After the threatment,UAE decreased in both of the two groups compared with the value before the treatment(P0.05);the decrease in treatment groups was more obvious than that in the control group(P0.05).Conclusion The combination of breviscapine and enalapril is effective on early diabetic nephropathy.