Clinical Observations of Telmisartan Combination Therapy with Amiodarone in Patients with Paroxysmal Atrial Fibrillation

Objective:To evaluate the clinical effieacy of Telmisartan in combination with Amiodarone on maintenance of sinus rhythm in patients with idiopathic paroxysmal atrial fibrillation(PAF).Methods:One hundred and twenty-one patients with idiopathic PAF were included in the study and randomly divided into two groups:group A was treated with amiodarone alone,group B was treated with amiodarone and telmisartan in combination.The left atrial diameter(LAD)was measured with transthoracic echocardiogram at before and after 6、12、18 and 24month of treatment.The duration of observation was up to one and half years and the primary end point of the study was the first recurrence of AF.Results:After 12 months,LAD in group A was significantly larger than that in group B(P0.05),the sinus rhythm maintenance of group A was lower significantly than that of group B.At the end of the study,the maintenance of sinus rhythm in groupB was higher significantly than that in group A.Conclusion:The results of this study suggest that the combination of amiodarone with telmisartan are more effective than amiodarone alone in sinus rhythm maintenance for idiopathic PAF,and may restrain the enlargement of the left atrium.