Postoperative patient-controlled intravenous analgesia with butorphanol and fentanyl in patients underwent hysterectomy

Objective To observe the efficacy and side effects of butorphanol and fentanyl for postoperative patient-controlled intravenous analgesia (PCIA). Methods Sixty patients underwent hysterectomy were randomly divided into 3 groups with 20 cases each.Butorphanol 5 mg combined with fentanyl 0.5 mg was used in group A,butorphanol 10 mg in group B or fentanyl 1.0 mg in group C was used alone.The drug of each case was added into normal saline 100 ml.PCIA was set 2 ml/h for background infusion and PCA dose was 0.5 ml with a lock time of 15 min. VAS scores,BP,HR,SpO2 and adverse effects were recorded at 4,8,12,24 and 48 h after operation. Results Analgesia was all satistactory in three groups.VAS scores were higher in group B than those in groups of A and C at 4,8 and 12 h(P0.05),which were still less than 2. BP,HR,SpO2 were all in the normal limits.The incidence of nausea and vomiting was higher in group C than that in the other groups(P0.01). Conclusion Compared with fentanyl,PCIA with butorphanol may provide a satisfactory postoperative analgesia with less adverse effects.