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2011•Medical Journal of CommunicationsRequires access

The influence of penehyclidine hydrochloride treatment on HMGB1 and SP-A expression in rats with Acute Necrotizing Pancreatitis-associated Acute Lung Injury

Yan-Bo Shen

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Abstract

Objective:To observe the influence of penehyclidine hydrochloride treatment on HMGB1 and SP-A expression in rats with acute necrotizing pancreatitis-associated acute lung injury.To investigate the efficacy of penehyclidine hydrochloride treatment in rats with acute necrotizing pancreatitis-associated acute lung injury.Methods:One hundred rats were randomly divided into two groups: the acute necrotizing pancreatitis group(the ANP group) and the group treated with penehyclidine hydrochloride(the PHCD group).Animals in each group were sacrificed at 6 h,12 h,24 h,36 h and 48 h after treatment respectively.The levels of HMGB1 and SP-A in serum and SP-A in BALF were measured by ELISA.Results: In the PHCD group,the levels of HMGB1 and SP-A in serum were significantly lower than those in the ANP group(P0.01).The levels of SP-A in BALF were significantly higher than those in the ANP group(P0.01).Conclusion:Penehyclidine hydrochloride has lung protective effect on acute necrotizing pancreatitis with acute lung injury through inhibiting the expression of HMGB1 and SP-A in serum and promoting the expression of SP-A in BALF.

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Objective:To observe the influence of penehyclidine hydrochloride treatment on HMGB1 and SP-A expression in rats with acute necrotizing pancreatitis-associated acute lung injury.To investigate the efficacy of penehyclidine hydrochloride treatment in rats with acute necrotizing pancreatitis-associated acute lung injury.Methods:One hundred rats were randomly divided into two groups: the acute necrotizing pancreatitis group(the ANP group) and the group treated with penehyclidine hydrochloride(the PHCD group).Animals in each group were sacrificed at 6 h,12 h,24 h,36 h and 48 h after treatment respectively.The levels of HMGB1 and SP-A in serum and SP-A in BALF were measured by ELISA.Results: In the PHCD group,the levels of HMGB1 and SP-A in serum were significantly lower than those in the ANP group(P0.01).The levels of SP-A in BALF were significantly higher than those in the ANP group(P0.01).Conclusion:Penehyclidine hydrochloride has lung protective effect on acute necrotizing pancreatitis with acute lung injury through inhibiting the expression of HMGB1 and SP-A in serum and promoting the expression of SP-A in BALF.

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Available abstract

Objective:To observe the influence of penehyclidine hydrochloride treatment on HMGB1 and SP-A expression in rats with acute necrotizing pancreatitis-associated acute lung injury.To investigate the efficacy of penehyclidine hydrochloride treatment in rats with acute necrotizing pancreatitis-associated acute lung injury.Methods:One hundred rats were randomly divided into two groups: the acute necrotizing pancreatitis group(the ANP group) and the group treated with penehyclidine hydrochloride(the PHCD group).Animals in each group were sacrificed at 6 h,12 h,24 h,36 h and 48 h after treatment respectively.The levels of HMGB1 and SP-A in serum and SP-A in BALF were measured by ELISA.Results: In the PHCD group,the levels of HMGB1 and SP-A in serum were significantly lower than those in the ANP group(P0.01).The levels of SP-A in BALF were significantly higher than those in the ANP group(P0.01).Conclusion:Penehyclidine hydrochloride has lung protective effect on acute necrotizing pancreatitis with acute lung injury through inhibiting the expression of HMGB1 and SP-A in serum and promoting the expression of SP-A in BALF.

Key concepts: Acute pancreatitis, HMGB1, Medicine, Lung, Gastroenterology, Internal medicine, Diffuse alveolar damage, Pancreatitis

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The influence of penehyclidine hydrochloride treatment on HMGB1 and SP-A expression in rats with Acute Necrotizing Pancreatitis-associated Acute Lung Injury — Research Paper | ScholarLens