Effects of Penehyclidine Hydrochloride on Traumatic Acute Lung Injury-Induced Proinflammatory Cytokine Production in Rats

Objective: To study the effects of Penehyclidine hydrochloride on the inflammatory reaction and their potential treatment mechanism in traumatic acute lung injury(ALI).Methods: Rat models of traumatic ALI were used in this study,and were randomly divided into normal control group(C),trauma model group(M) and Penehyclidine hydrochloride intervention group(P),with 24 rats in each group.The effects of penehyclidine hydrochloride on arterial blood gas,lung wet/dry(W/D) ratio,lung myeloperoxidase(MPO) activity,serum tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) level were observed.Light and electron microscopy were also performed to detect the injury of lung tissue.Results: Penehyclidine hydrochloride could significantly improve the blood gas results(P0.05),reduce the lung W/D weight ratio(P0.05) and MPO activity(P0.05),decrease the plasma level of TNF-α and IL-6(P0.01,P0.05),and relieve the lung tissue injury in the traumatic ALI rats.Conclusion: Penehyclidine hydrochloride plays anti-inflammatory and protective roles in traumatic ALI through mediating the proinflammatory cytokines.