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Nspection stability of Cefotaxime sodium in sodium chloride injection

Wan Jing

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Abstract

[Objetive] Inspection the stability Cefotaxime sodium in sodium chloride injection.[Methods] Uses the classical constant temperature method,and inspects the pH value of sodium chloride injection,and uses the highly effective liquid phase chromatograph instrumental measurement to test the content of Cefotaxime sodium.[Results] The Cefotaxime sodium solusion 4℃ time term of validity(t0.9) is 14 h,the pH is 4.88,25℃ its term of validity are(t0.9) 4 h,the pH is 4.72.[Conclusion] This thermostability is worse,4℃ constant temperatures preservation not suitably surpass the 14 h room temperature evade the light not suitably surpassed 4 hours.

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[Objetive] Inspection the stability Cefotaxime sodium in sodium chloride injection.[Methods] Uses the classical constant temperature method,and inspects the pH value of sodium chloride injection,and uses the highly effective liquid phase chromatograph instrumental measurement to test the content of Cefotaxime sodium.[Results] The Cefotaxime sodium solusion 4℃ time term of validity(t0.9) is 14 h,the pH is 4.88,25℃ its term of validity are(t0.9) 4 h,the pH is 4.72.[Conclusion] This thermostability is worse,4℃ constant temperatures preservation not suitably surpass the 14 h room temperature evade the light not suitably surpassed 4 hours.

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Available abstract

[Objetive] Inspection the stability Cefotaxime sodium in sodium chloride injection.[Methods] Uses the classical constant temperature method,and inspects the pH value of sodium chloride injection,and uses the highly effective liquid phase chromatograph instrumental measurement to test the content of Cefotaxime sodium.[Results] The Cefotaxime sodium solusion 4℃ time term of validity(t0.9) is 14 h,the pH is 4.88,25℃ its term of validity are(t0.9) 4 h,the pH is 4.72.[Conclusion] This thermostability is worse,4℃ constant temperatures preservation not suitably surpass the 14 h room temperature evade the light not suitably surpassed 4 hours.

Key concepts: Sodium, Thermostability, Cefotaxime, Chemistry, Chromatography, Organic chemistry, Biochemistry, Antibiotics

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