Analysis of Pantoprazole,Trimebutine Combined with Flupentixol and Melitracen Tablets in the Treatment of Gastroesophageal Reflux Disease

Objective:To observe clinical curative effect of Pantoprazole, Trimebutine combined with Flupentixol and Melitracen tablets in the treatment of gastroesophageal reflux disease.Method:120 cases of gastroesophageal reflux disease in our hospital from January 2012 to October 2013 were selected, and they were divided into the experimental group for 63 cases and the control group for 57 cases according to the patients with voluntary basis. The experimental group was treated with Pantoprazole, Trimebutine combined with Flupentixol and Melitracen tablets; the control group was given Pantoprazole, Trimebutine, a course of 4 weeks. The clinical therapeutic effect and drug withdrawal after 3 months,the recurrence rate and adverse reactions were compared between the two groups.Result:The total effective rate of the experimental group was higher than the control group, the difference was statistically significant(P0.05); Withdrawal after 3 months, the recurrence rate of the experimental group was lower than the control group, the difference was statistically significant(P0.05); after treatment, SAS, SDS value of the experimental group were significantly lower, compared with the control group were statistically significant difference(P0.01); patients of the two groups had no obvious adverse reaction in treatment.Conclusion: Pantoprazole, Trimebutine combined with Flupentixol and Melitracen tablets in the treatment of gastroesophageal reflux disease can effectively improve the clinical symptoms, and can effectively prevent its recurrence, curative effect is distinct, is worth popularizing in clinical application.