Observation on the level of oxygen lesion in patients with acute parapuat poisoning

Objective To explore the variations of oxygen free radical(OFR) in the patients of acute paraquat poisoning(APP). Methods The levels of serum malondialdehyde(MDA) and super-oxide dismutase(SOD) in 68 APP patients were measured by the methods of thiobarbiturate and xanthin oxidase at the time of hospitalization,24h,48h,72h after poisoning,and compared with 29 healthy individuals. Results The levels of serum MDA in APP patients were significantly increased than that of control group(P0.01),and it was increased significantly from 24 hours to 48 hours after poisoning(P0.001).The levels of serum SOD decreased obviously in APP patients(P0.01).the levels of serum MDA in death patients was higher than that of survival patients,while the levels of serum SOD in the survival patients were lower than that of survival patients.there ware significant difference in the two groups(P0.01). Conclusion OFR lesion is one of the importance factor in the pathogenesis of APP.Serum MDA and SOD can be taken as the clinical indexes for evaluating the degree of multiple organ function damage,guiding treatment and judging the prognosis of APP.