Study on Relationship between Endothelin And Oxgen Free Radical with Acute Paraquat Poisoning

Objective:To explore the effects and relationship between endothelin(ET) and oxygen free radical(OFR) in the pateans with acute paraquat poisoning(APP).Methods:The levels of plasma ET,serum malondial dehyde(MDA) and super-oxide dismutase(SOD) were measured by the methods of nalysis of radioimmunoassay,thiobarbiturate and xanthin oxidasein the blood samples from 68 patients with APP,and 29 normal controls.Results:The levels of plasma ET and serum MDA in patients with APP were much higher than controls,and the levels of plasma ET and serum MDA in death group was much higher than that of survivor group(P0.01 or P0.05).The levels of serum SOD decreased obviously in APP(P0.01 or P0.001),and there was significant difference in death group and survivor group(P0.05).Plasma ET was a positively correlated with serum MDA,while there was a negative correlation with serum SOD(P0.01).Conclusion:OFR is one of the importance fact in jury or in the pathogenesis of APP.The increased levels of ET may involved in the pathogenesis of APP.Plasma ET,MDA and SOD may be of a clinical index for evaluating the degree of thedisease,for guiding tyeatment,and judging the prognosis of APP.