2005•Journal of Clinical CardiologyRequires access
Protection of doxycycline on cardiac function after myocardial infarction in rats
Jianzhong Guo
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Abstract
Objective:Protection of doxycycline(extragenous inhibitor of matrix metalloproteinases) on cardiac function was observed following myocardial infarction in rats by echocardiography.Method:The descending left coronary artery of male rats(Sprague-dawley) was ligated to produce a myocardial infarction model.Thirty-onerats were randomly divided into two groups: myocardial infarction(Group MI,n=15) and doxycycline(Group D,n=16).The thickness of left ventricular wall,the diastolic diameter of left ventricular and EF were measured by echocardiography(Acuson Sequoia 512) on the 2nd and 4th week.Result:The weight of left ventricle in group D was lighter than that in group MI(P0.05);The thickness of anterior wall in group D was larger than that in group MI(P0.05);LVDd in group MI was larger than that in group D(P0.05).Conclusion:Doxycycline can improve the cardiac function following myocardial infarction.The mechanism may be interrelated with extragenous inhibitor of matrix metalloproteinases participation in ventricular remodeling.