Study the clinical values of serum CysC,Hcy,hs-CRP and U-mAlb in diabetes patients with early renal damage

Objective To investigate the diagnostic value of combined detection of serum cystatin C (CysC), homocysteine (Hcy),high sensitivity C-reactive protein (hs-CRP)and urine micro-albumin (U-mAlb) in type-2 diabetic mellitus (T2DM) patients with early diabetic nephropathy. Methods 126 T2DM patients and 80 normal subjects were studied. Nephelometry and the colorimetry were respectively used to test for the levels of serum CysC ,Hcy,hs-CRP and morning U-mAlb. Results The levels of serum CysC,Hcy,hs-CRP and U-mAlb in patients with T2DM were significantly higher than those in control group (P0.01). The sensitivity of detection of serum CysC,Hcy,hs-CRP and U-mAlb were 60.32%, 75.40%, 84.13% and 63.49%, respectively. The specificity was 95～100%. The positive rate in patients with T2DM was significantly higher than the control (P0.001). Combined determination of serum CysC,Hcy,hs-CRP and U- mAlb would increase the sensitivity to 96.83%. There was a positive correlation in the increase of CysC , Hcy, hs-CRP and U-mAlb (r=0.952、0.971、0.926,P0.01). Conclusion The levels of serum CysC,Hcy,hs-CRP and U-mAlb may all be used as sensitive indicators for the diagnosis of early diabetic nephropathy in T2DM patients.