Diagnostic value of serum cystatin C,homocysteine and high sensitivity C-reactive protein in diabetic nephropathy

Objective:To study the diagnostic value of the combined detection of serum cystatin C(Cys C),homocysteine(HCY)and high sensitivity C-reactive protein(hs-CRP)in diabetic nephropathy.Method:The changes of serum Cys C,HCY and hs-CRP in 175cases of DM patients and 40healthy control group were compared.The serum Cys C and hs-CRP were conducted by using latex particle enhanced immunoturbidimetric assay,the serum HCY was conducted by using cycle enzymatic assay.Meanwhile,the rates of combined detection were analyzed.Result:DM patients with normal albuminuria group,serum Cys C,HCY and hs-CRP level were significantly higher than those of normal control group(P0.05),serum Cys C and HCY levels were higher significantly(P0.01)in DM patients with microalbuminuria and clinical proteinuria than normal control group,the level of serum Cys C,HCY and hs-CRP gradually increased with the occurrence and severity of diabetic nephropathy.Conclusion:The detection of serum Cys C,HCY and hs-CRP could be used as a sensitive indicator for early diagnosis of DN and monitoring the occurrence of early DN and the degree of progression of the disease.