The expression and clinical significance of IL-6、IL-8 、IL-10 and TNF-α in severe multiple injuries after Ulinastatin treatment

Objective To investigate the expression and clinical significance of IL-6、IL-8 、IL-10 and TNF-α in severe multiple injuries after Ulinastatin treatment.Methods 80 cases of severe multiple injuries were divided into treatment group(40 cases with Ulinastatin treatment) and control group(40 cases with no Ulinastatin treatment).The level of IL-6、IL-8、 IL-10 and TNF-α in veno-blood serum were detected when the 0.5、1、2、3、5、7 days after trauma,Compare the difference between the two groups.Results The level of IL-6、IL-8、 IL-10 and TNF-α increased immediately after trauma,and the peak value was achieved at 1-3days.The level of these cytokines in treatment group were lower than those in control group at prophase.there was statistical significance in two groups(P0.01).Ulinastatin can promote the level of anti-inflammatory IL-10 at prophase.there was statistical significance in two groups(P0.01).Conclusion Ulinastatin can reduce the the level of IL-6、IL-8、and TNF-α(proinflammatory factor),but it can promote the level of IL-10(anti-inflammatory factor).Ulinastatin can inhibit the inflammatory reaction of severe multiple injuries and improve the achievement ratio.