Study of the Influence of Ulinastatin Intervention on Cytokines in Patients with Severe Acute Organophosphorous Pesticide Poisoning

Objective To investigate the influence of ulinastatin intervention on the dynamic variation of interleukin- 6,interleukin-10 and Tumor necrotic factor-or in patients with multiple organ dysfunction syndrome caused by severe acute organophosphorus pesticide poisoning(AOPP).Methods 46 patients with MODS casued by severe AOPP were randomly and clinically divided into conventional group(24 patients) and ulinastatin intervention group (22 patients).The dynamic variations of these cytokines were detected synchronizingly and compared with healthy control group(20 patients).Results The levels of IL-6、IL-10 and TNF-α in serum of both of conventional therapy group and ulinastatin intervention group were higher than heahy control group(P0.01) and decreased obviously after therapy(P0.01).The contents of IL-6 and TNF-α of ulinastatin intervention group after therapy had a greater decrease than conventional therapy group (P 0.01),but there was no significant difference when compared with IL-10 (P0.05).The case fatality of ulinastatin inter- vention group was lower obviously than conventional therapy group,and the length of stay in hospital was also shor- ter.Conclusion TNF-α,IL-6 and IL-10 have effects on the pathological process of MODS caused by severe AOPP.Ulinastatin can obviously decrease the levels of TNF-α and IL-6,which conduce to the decrease of case fatality of se- vere AOPP patients with MODS.