Distribution and antimicrobial resistance of 2 208 clinically isolated pathogens

Objective To analyze the distribution and antimicrobial resistance of common pathogens isolated from a hospital,and provide reference for rational antimicrobial use.Methods Data of 2 208 pathogens from clinical specimens from January 2011 to December 2012 were analyzed retrospectively by WHONET5.5 software.Results A total of 2 208 pathogens were isolated,pathogens were mainly isolated from sputum(50.63%,1 118/2 208)and urine(22.69%,501/2 208).1 418(64.22%)isolates were gram-negative bacteria,Escherichia coli was the most common gram-negative bacillus(15.72%),followed by Klebsiella pneumoniae(11.96%),Acinetobacter baumannii(10.64%),and Pseudomonas aeruginosa(9.83%);577(26.13%)isolates were gram-positive bacteria,11.23%of which were Staphylococcus aureus;213(9.65%)isolates were fungi.Gram-negative bacilli were sensitive to imipenem,but resistance of Acinetobacter baumannii was serious(resistant rate was 55.74%-74.04%).The percentage of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase negative Staphylococcus was 69.76% and 87.56%respectively,no Staphylococcus spp.isolates was found to be resistant to vancomycin.ConclusionThe main infection site of patients in this hospital is respiratory tract;antimicrobial resistance of pathogens is serious,intensified surveillance on antimicrobial resistance is important to guide rational use of antimicrobial agents and reduce multidrug resistant strain.