Furosemide Test Predicts Hematoma Enlargement in Patients of Hypertensive Cerebral Hemorrhage

Objective To study the validity of furosemide test for predicting the hematoma enlargement in pa- tients with hypertensive cerebral hemorrhage.Methods Four hundred fifty-one patients with hypertensive cerebral hemorrhage were diagnosed using CT after oneset of the disease and 24 h reexamined 24 h after.The incidence of enlarged hematoma was evaluated by comparison the baseline and 24 h CT scanning.Furosemide(20 mg iv)was ad- ministered and blood pressure was measured 30 min after furosemide.Results The decreasing level of MAP after furosemide was significantly inversely related with incidence rate of hematoma enlargement{ r=-0.94,t=58.4,P 0.01).Using MAP decreased10 mmHg as the cut-off point,with the rate of hematoma enlargement as being 6.4 %,MAP decreased≤10 mmHg was associated with increases in prevalence of hematome to 33.2 %(χ~2=51.82, P0.01).The sensitivety of furosemide test to predict hematoma enlargement was 82.8%.Conclusion MAP redcution for ≤10 rnmHg after 20 mg 1 V furosemide may potentially serve as a predictor for the enlargement of he- matome after cerebral hemorrhage.