Clinical Disposition and Drug Resistance Transition in Pseudomonas aeruginosa

OBJECTIVE To investigate clinical distribution,drug resistance and transition of Pseudomonas aeruginosa in the Affiliated Hospital of Ningbo University and guide rational clinical use of drug.METHODS The sample′s origin,clinical distribution and drug resistance of 454 P.aeruginosa isolates were analyzed by retrospectively investigation.RESULTS 64.9% P.aeruginosa isolated from sputum and throat swab and 50.44% of P.aeruginosa infection occurred in ICU.Antibiotic resistance to 17 kinds of antibacterials increased from 2006 to 2007 but were controlled in 2008.Imipenem,piperacillin/tazobactam,amikacin and cefoperazone/sulbactam were sensitive in P.aeruginosa.Antibiotic resistance to ampicillin,cefazolin,ampicillin/sulbactam nitrofurantoin and SMZ-TMP were 16.74%,18.50%,21.59% and 24.23%.CONCLUSIONS P.aeruginosa is one of the most cornmon pathogen in hospital infection.It is important for rational administration according to susceptibility test.