Effects of Rhubarb against Microinflammation and Oxidative Stress Status in Nondialysed Patients with Uremia

Objective To investigate the efficacy of rhubarb on microinflammation and oxidative stress status in nondialysed patients with uremia.Methods Forty-seven nondialysed patients with uremia were randomly allocated to observation group and treatment group,another 20 healthy volunteers were served as control group.Patients in treatment group were administered with infused decotion of rhubarb for 2 months.The blood levels of high sensitivity C-reactive protein(hs-CRP),tumour necrosis factor-α(TNF-α),interleukin-6(IL-6),malonaldehyde(MDA)and glutathione peroxidase(GSHPx)were measured before and after the treatment,respectively.Results Compared with control group,the levels of hs-CRP,TNF-α,IL-6 and MDA in both observation group and treatment group before therapy were significantly increased(P0.01,respectively),the concentration of GSHPx was significantly decreased(P0.01).The levels of hs-CRP,TNF-α,IL-6 and MDA after therapy were significant lower than those before treatment(P0.01,respectively),and the concentration of GSHPx after therapy was significant higher than that before therapy(P0.01).There were a significant difference on these indexes between treatment group and observation group after treatment.Conclusion Rhubarb could effectively improve microinflammation and oxidative stress status in nondialysed patients with uremia.