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Clinical Significance and Expression of p16~(INK4a) and HPV16/18-E6 in Cervix Tissue

Hu Jian

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Abstract

Objective To explore the expression and clinical significance of p16INK4a and HPV16/18-E6 in different cervix tissues,and to explore the biological marker of progression and prognosis in cervix precancerosis and cancer.Methods The expressions of p16INK4a and HPV16/18-E6 of different cervix tissue were examined with immunohistochemistry methed.Results The ex-pression of p16INK4a and HPV16/18-E6 was negative or weakly positive in normal cervix tissue,chronic cervicitis tissue and cervical intraepithelial neoplasia(CIN) I,respectively,and were signifi-cantly enhanced in CIN Ⅲ and cervix cancer(P0.01).The expression of p16INK4a in cervix cancer was significantly related to cell differentiation and degree of muscular layer infiltrate(P0.01).Conclusion The expression of HPV16/18-E6 is highly related to p16INK4a in CIN Ⅲ and cervix cancer.To combine detection of p16INK4a and high risk-HPV(HR-HPV) may elevate the early di-agnosis rate in CIN and cervix cancer.

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Objective To explore the expression and clinical significance of p16INK4a and HPV16/18-E6 in different cervix tissues,and to explore the biological marker of progression and prognosis in cervix precancerosis and cancer.Methods The expressions of p16INK4a and HPV16/18-E6 of different cervix tissue were examined with immunohistochemistry methed.Results The ex-pression of p16INK4a and HPV16/18-E6 was negative or weakly positive in normal cervix tissue,chronic cervicitis tissue and cervical intraepithelial neoplasia(CIN) I,respectively,and were signifi-cantly enhanced in CIN Ⅲ and cervix cancer(P0.01).The expression of p16INK4a in cervix cancer was significantly related to cell differentiation and degree of muscular layer infiltrate(P0.01).Conclusion The expression of HPV16/18-E6 is highly related to p16INK4a in CIN Ⅲ and cervix cancer.To combine detection of p16INK4a and high risk-HPV(HR-HPV) may elevate the early di-agnosis rate in CIN and cervix cancer.

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Available abstract

Objective To explore the expression and clinical significance of p16INK4a and HPV16/18-E6 in different cervix tissues,and to explore the biological marker of progression and prognosis in cervix precancerosis and cancer.Methods The expressions of p16INK4a and HPV16/18-E6 of different cervix tissue were examined with immunohistochemistry methed.Results The ex-pression of p16INK4a and HPV16/18-E6 was negative or weakly positive in normal cervix tissue,chronic cervicitis tissue and cervical intraepithelial neoplasia(CIN) I,respectively,and were signifi-cantly enhanced in CIN Ⅲ and cervix cancer(P0.01).The expression of p16INK4a in cervix cancer was significantly related to cell differentiation and degree of muscular layer infiltrate(P0.01).Conclusion The expression of HPV16/18-E6 is highly related to p16INK4a in CIN Ⅲ and cervix cancer.To combine detection of p16INK4a and high risk-HPV(HR-HPV) may elevate the early di-agnosis rate in CIN and cervix cancer.

Key concepts: Cervix, Immunohistochemistry, Cervicitis, Cervical cancer, Medicine, Cervical intraepithelial neoplasia, Cancer, Clinical significance

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